Jie Chen, YeZhou, Yu Xu, Hui-yan Zhu, Ying-qiang Shi

Department of GastricCancer and Soft Tissue Sarcomas, Fudan University Shanghai CancerCenter

Objective:High serum albumin (ALB) andalbumin/globulin ratio (AGR) have been reported to be associated with afavorable prognosis for several types of cancer. However, little is known aboutprognostic significance of ALB, AGR and globulin (GLB) in gastric cancerpatients. The purpose of this study was to evaluate whether ALB, GLB and AGRanalysis could predict the prognosis of patients with gastric cancer. Method:This retrospective study examined a cohort of 186 patients with gastric cancerwho had documented preoperative ALB and GLB. AGR was calculated as [AGR=ALB/GLB].Survival analysis was used to evaluate the predictive value of ALB, GLB andAGR. Result: X-tile program determined 37.6, 33.4 and 1.33 as theoptimal cut-off value for ALB, GLB and AGR in terms of survival. Univariateanalysis revealed that low GLB levels and high ALB level were significantlyassociated with favorable survival (P=0.045 and P=0.000,respectively). Multivariate analysis showed that low AGR were associated withsignificantly poor survival (P=0.004). Conclusion: Lowpreoperative GLB level may be a significantly favorable factor for gastriccancer patients. Therefore, the level of preoperative GLB may serve asavaluable marker to predict the prognosis.

KeyWords: Gastric cancer  Globulin  Prognosis